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Report

Genome-Based Therapeutics: Targeted Drug Discovery and Development - Workshop Summary

Released:: September 5, 2012
Type:: Workshop Summary
Topics:: Biomedical and Health Research, Public Health
Activity:: Roundtable on Translating Genomic-Based Research for Health
Board:: Board on Health Sciences Policy

Note: Workshop Summaries contain the opinion of the presenters, but do NOT reflect the conclusions of the IOM. Learn more about the differences between Workshop Summaries and Consensus Reports.

The number of new drug approvals has remained steady for the last 50 years while spending on health-related research and development has tripled since 1990. This trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to increase efficiency and lower costs, while producing more effective drugs in the process. Genomic information has significantly increased our understanding of disease and the integration of genome-based strategies into drug discovery and development processes has resulted in the recent successful development of a number of new targeted therapeutics. However, there remains skepticism over how useful genomic information will be to the larger drug development process, requiring examination of the impact of and challenges for incorporating genome-based strategies. On March 21, 2012, the IOM’s Roundtable on Translating Genomic-Based Research for Health held a workshop to examine the general approaches being used to apply genome-based research results to the discovery and development of new drugs, the successes achieved so far, and the challenges ahead. This document summarizes the workshop.
For additional resources, such as the agenda and presentations, please visit the workshop page.