Also in the Journals: Genetic Factors Linked to Lung Cancer in Asian Women Who Have Never Smoked
Researchers have identified three more regions of the genome that may play a role in the development of lung cancer in Asian women who have never smoked. One variant is on chromosome 10 and two are on chromosome 6. The study also confirmed previous reports linking regions of chromosomes 5, 3, and 17 to lung cancer in Asian women who have never smoked.
Women with one of the three newly identified genetic variants may be more susceptible to lung cancer caused by environmental exposures, including secondhand smoke, the researchers found, although this needs to be replicated in other studies. Contrary to previous research, this study found no evidence that a variant on chromosome 15 is associated with lung cancer in Asian women who have never smoked, which suggests that this variant may be smoking related.
The genome-wide association study included data from 14 studies and compared the genomes of 6,600 Asian women with lung cancer and 7,500 without lung cancer. Dr. Qing Lan of NCI’s Division of Cancer Epidemiology and Genetics and her colleagues published their findings November 11 in Nature Genetics.
This study was supported by the National Institutes of Health (ZIACP010121).
Researchers have identified three more regions of the genome that may play a role in the development of lung cancer in Asian women who have never smoked. One variant is on chromosome 10 and two are on chromosome 6. The study also confirmed previous reports linking regions of chromosomes 5, 3, and 17 to lung cancer in Asian women who have never smoked.
Women with one of the three newly identified genetic variants may be more susceptible to lung cancer caused by environmental exposures, including secondhand smoke, the researchers found, although this needs to be replicated in other studies. Contrary to previous research, this study found no evidence that a variant on chromosome 15 is associated with lung cancer in Asian women who have never smoked, which suggests that this variant may be smoking related.
The genome-wide association study included data from 14 studies and compared the genomes of 6,600 Asian women with lung cancer and 7,500 without lung cancer. Dr. Qing Lan of NCI’s Division of Cancer Epidemiology and Genetics and her colleagues published their findings November 11 in Nature Genetics.
This study was supported by the National Institutes of Health (ZIACP010121).
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