lunes, 3 de diciembre de 2012

Landmarks of the HIV genome

here please:
Landmarks of the HIV genome

Landmarks of the HIV-1 genome, HXB2 strain (above). Open reading frames are shown as rectangles. The gene start, indicated by the small number in the upper left corner of each rectangle, normally records the position of the a in the ATG start codon for that gene, while the number in the lower right records the last position of the stop codon. For pol, the start is taken to be the first T in the sequence TTTTTTAG, which forms part of the stem loop that potentiates ribosomal slippage on the RNA and a resulting -1 frameshift and the translation of the Gag-Pol polyprotein. The tat and rev spliced exons are shown as shaded rectangles. In HXB2, *5772 marks position of frameshift in the vpr gene caused by an "extra" T relative to most other subtype B viruses; !6062 indicates a defective ACG start codon in vpu; †8424, and †9168 mark premature stop codons in tat and nef. See Korber et al., Numbering Positions in HIV Relative to HXB2CG, in the database compendium, Human Retroviruses and AIDS, 1998.

A list of HXB2 coordinates of many HIV-1 genes and structural elements is posted in Search Interface Help.

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