PLOS Biology: How HIV Sneaks aboard Mature Dendritic Cells
Citation: Sedwick C (2012) How HIV Sneaks aboard Mature Dendritic Cells. PLoS Biol 10(12): e1001454. doi:10.1371/journal.pbio.1001454
Published: December 18, 2012
Copyright: © 2012 Caitlin Sedwick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing interests: The author has declared that no competing interests exist.
* E-mail: csedwick@gmail.com
The receptor Siglec-1 (green) captures and retains HIV (red) within the cytoplasm of a mature dendritic cell (grey). Both HIV and Siglec-1 accumulate in a sac-like compartment (yellow) near the dendritic cell nucleus (blue).
Image credit: Maria Pino, Itziar Erkizia, and Nuria Izquierdo-Useros.
doi:10.1371/journal.pbio.1001454.g001
HIV, the virus that causes AIDS, has an extensive repertoire of tricks that it uses to evade, manipulate, and subvert the human immune system. Perhaps most insidious is the virus's ability to turn the immune system's defensive tactics to its own advantage. For example, HIV-1 (the virus that causes most cases of HIV infection) uses a type of immune cell, the dendritic cell (DC), to spread its infection.
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