sábado, 19 de enero de 2013

Epidemiology of pneumococcal sero... [Diagn Microbiol Infect Dis. 2012] - PubMed - NCBI

Diagn Microbiol Infect Dis. 2012 Dec 28. pii: S0732-8893(12)00504-4. doi: 10.1016/j.diagmicrobio.2012.11.021. [Epub ahead of print]

Epidemiology of pneumococcal serotype 6A and 6C among invasive and carriage isolates from Alaska, 1986-2009.

Rudolph K, Bruce M, Bruden D, Zulz T, Wenger J, Reasonover A, Harker-Jones M, Hurlburt D, Hennessy T.

Source

Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK 99508, USA.

Abstract

We investigated serotype 6A/6C invasive pneumococcal disease (IPD) incidence, genetic diversity, and carriage before and after 7-valent pneumococcal conjugate vaccine (PCV7) introduction in Alaska. IPD cases (1986-2009) were identified through population-based laboratory surveillance. Isolates were initially serotyped by conventional methods, and 6C isolates were differentiated from 6A by polymerase chain reaction. Among invasive and carriage isolates initially typed as 6A, 35% and 50% were identified as 6C, respectively. IPD rates caused by serotype 6A or 6C among children <5 0.001="0.001" 0.004="0.004" 0.71="0.71" 1.8="1.8" 2008-2009="2008-2009" 28="28" 3.0="3.0" 6a="6a" 6c="6c" 7.4="7.4" 8.4="8.4" among="among" and="and" carriage="carriage" change="change" changes="changes" children="children" continued="continued" decreased="decreased" did="did" distribution="distribution" during="during" from="from" in="in" increased="increased" ipd="ipd" is="is" isolates="isolates" monitor="monitor" multilocus="multilocus" not="not" of="of" p="p" period="period" post-pcv7="post-pcv7" pre-="pre-" pre-pcv7="pre-pcv7" prevalence.="prevalence." proportion="proportion" respectively="respectively" revealed="revealed" sequence="sequence" serotype="serotype" surveillance="surveillance" the="the" to="to" types.="types." typing="typing" warranted="warranted" years.="years." years="years">Published by Elsevier Inc.