lunes, 18 de marzo de 2013

Early diagnosis and treatment of ... [Expert Rev Cardiovasc Ther. 2013] - PubMed - NCBI

Early diagnosis and treatment of ... [Expert Rev Cardiovasc Ther. 2013] - PubMed - NCBI

2013 Mar;11(3):327-42. doi: 10.1586/erc.13.7.

Early diagnosis and treatment of familial hypercholesterolemia: improving patient outcomes.

Source

Lipid Clinic, Internal Medicine Department, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Abstract

Familial hypercholesterolemia (FH) is the most frequent inherited disorder associated with premature coronary artery disease. Early identification and treatment of patients will reduce cardiovascular outcomes. Identification of index cases and then cascade testing in first-degree relatives using lipid levels and genetic test is the most cost-effective strategy implemented in some countries. FH patients are considered at high cardiovascular risk. Imaging techniques such as coronary computed tomography angiography could identify subjects that will require more intensive treatments. Recent guidelines recommend an LDL-C below 100 mg/dl or at least 50% LDL-C reduction if the first goal is not attained as treatment targets in heterozygous FH. Statins are the first-line agents in almost all patients, and several options exist to obtain larger LDL-C reductions like the addition of ezetimibe and/or colesevelam. Novel agents like microsomal triglyceride transfer protein inhibitors, apolipoprotein B100 antisense or PCSK9-specific monoclonal antibodies, if approved by regulatory agencies, will reduce LDL-C levels and potentially reduce cardiovascular risk in homozygous and severe heterozygous FH patients.

PMID:
23469913
[PubMed - in process]

No hay comentarios:

Publicar un comentario