Human Betacoronavirus 2c EMC/2012–related Viruses in Bats, Ghana and Europe - Vol. 19 No. 3 - March 2013 - Emerging Infectious Disease journal - CDC
Table of Contents
Volume 19, Number 3– March 2013
Volume 19, Number 3—March 2013
Dispatch
Human Betacoronavirus 2c EMC/2012–related Viruses in Bats, Ghana and Europe
Article Contents
- The Study
- Conclusions
- Acknowledgments
- References
- Figure 1
- Figure 2
- Table 1
- Table 2
- Technical Appendix Figure [240 KB - 2 pages]
- Suggested Citation
Suggested citation for this article
Abstract
We screened fecal specimens of 4,758 bats from Ghana and 272 bats from 4 European countries for betacoronaviruses. Viruses related to the novel human betacoronavirus EMC/2012 were detected in 46 (24.9%) of 185 Nycteris bats and 40 (14.7%) of 272 Pipistrellus bats. Their genetic relatedness indicated EMC/2012 originated from bats.
Coronaviruses (CoVs) are enveloped viruses with a positive-sense, single-stranded RNA genome (1). CoVs are classified into 4 genera: Alphacoronavirus, Betacoronavirus (grouped further into clades 2a–2d), Gammacoronavirus, and Deltacoronavirus. Two human coronaviruses (hCoVs), termed hCoV-OC43 and −229E, have been known since the 1960s and cause chiefly mild respiratory disease (2). In 2002–2003, an outbreak of severe acute respiratory syndrome (SARS) leading to ≈850 deaths was caused by a novel group 2b betacoronavirus, SARS-CoV (3). A likely animal reservoir for SARS-CoV was identified in rhinolophid bats (4,5). In the aftermath of the SARS pandemic, 2 hCoVs, termed hCoV-NL63 and -HKU1, and numerous novel bat CoVs were described.
In September 2012, health authorities worldwide were notified of 2 cases of severe respiratory disease caused by a novel hCoV (6,7). This virus, termed EMC/2012, was related to the 2c betacoronavirus clade, which had only been known to contain Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 (8).
We previously identified highly diversified alphacoronaviruses and betacoronaviruses, but not clade 2c betacoronaviruses, in bats from Ghana (9). We also identified sequence fragments from a 2c betacoronavirus from 1 Pipistrellus bat in Europe (10). In this study, we analyzed an extended sample of 4,758 bats from Ghana and 272 bats from 4 European countries.
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