lunes, 12 de agosto de 2013

A multigene expression assay to predict l... [J Natl Cancer Inst. 2013] - PubMed - NCBI

A multigene expression assay to predict l... [J Natl Cancer Inst. 2013] - PubMed - NCBI

J Natl Cancer Inst. 2013 May 15;105(10):701-10. doi: 10.1093/jnci/djt067. Epub 2013 May 2.

A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast.

Source

Department of Radiation Oncology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA. solin@einstein.edu

Abstract

BACKGROUND:

For women with ductal carcinoma in situ (DCIS) of the breast, the risk of developing an ipsilateral breast event (IBE; defined as local recurrence of DCIS or invasive carcinoma) after surgical excision without radiation is not well defined by clinical and pathologic characteristics.

METHODS:

The Oncotype DX breast cancer assay was performed for patients with DCIS treated with surgical excision without radiation in the Eastern Cooperative Oncology Group (ECOG) E5194 study. The association of the prospectively defined DCIS Score (calculated from seven cancer-related genes and five reference genes) with the risk of developing an IBE was analyzed using Cox regression. All statistical tests were two-sided.

RESULTS:

There were 327 patients with adequate tissue for analysis. The continuous DCIS Score was statistically significantly associated with the risk of developing an IBE (hazard ratio [HR] = 2.31, 95% confidence interval [CI] = 1.15 to 4.49; P = .02) when adjusted for tamoxifen use (prespecified primary analysis) and with invasive IBE (unadjusted HR = 3.68, 95% CI = 1.34 to 9.62; P = .01). For the prespecified DCIS risk groups of low, intermediate, and high, the 10-year risks of developing an IBE were 10.6%, 26.7%, and 25.9%, respectively, and for an invasive IBE, 3.7%, 12.3%, and 19.2%, respectively (both log rank P ≤ .006). In multivariable analyses, factors associated with IBE risk were DCIS Score, tumor size, and menopausal status (all P ≤ .02).

CONCLUSIONS:

The DCIS Score quantifies IBE risk and invasive IBE risk, complements traditional clinical and pathologic factors, and provides a new clinical tool to improve selecting individualized treatment for women with DCIS who meet the ECOG E5194 criteria.

PMID:
23641039
[PubMed - indexed for MEDLINE]
PMCID:
PMC3653823
Free PMC Article
Images from this publication.See all images (4)Free text
Figure 1.
Figure 2.
Figure 3.
Figure 4.

No hay comentarios:

Publicar un comentario