Expert Group Report on Anesthetic Neurotoxicity
An NCTR scientist coauthored an article outlining the results of the British Journal of Anaesthesia Salzburg Seminar on Anaesthetic Neurotoxicity and Neuroplasticity; an expert workshop focused on the review of current anesthetic research from animal and human studies and the future direction of the field. The article highlighted recent NCTR studies using positron emission tomography (PET) to characterize the time course of anesthetic-induced injury, as well as behavioral studies that explore the long-term cognitive consequences (learning and memory) of the pediatric anesthetic ketamine. The consensus was that although clinical data is indecisive, preclinical data demonstrates the potential adverse effects of anesthetics on neural development and function. Thus, it is imperative to gain a better understanding of the mechanisms of anesthetic-induced neurotoxicity to aid in the development of protective strategies. The report was published in the British Journal of Anaesthesia
(2013, 111:143-151).For additional information, please contact William Slikker, Jr., Ph.D., Director, FDA/NCTR.
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