jueves, 26 de septiembre de 2013

Persistent Human Cosavirus Infection in Lung Transplant Recipient, Italy - Vol. 19 No. 10 - October 2013 - Emerging Infectious Disease journal - CDC

full-text ►
Persistent Human Cosavirus Infection in Lung Transplant Recipient, Italy - Vol. 19 No. 10 - October 2013 - Emerging Infectious Disease journal - CDC


EID cover artwork EID banner
Table of Contents
Volume 19, Number 10–October 2013



Volume 19, Number 10—October 2013

Dispatch

Persistent Human Cosavirus Infection in Lung Transplant Recipient, Italy

Giulia Campanini, Francesca Rovida, Federica Meloni, Alessandro Cascina, Rachele Ciccocioppo, Antonio Piralla, and Fausto BaldantiComments to Author 
Author affiliations: Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy (G. Campanini, F. Rovida, A. Cascina, A. Piralla, F. Baldanti); Università degli Studi di Pavia, Pavia (F. Meloni, R. Ciccocioppo)
Suggested citation for this article

Abstract

Human cosavirus is a novel picornavirus recently identified in feces from children in southern Asia. We report infection with human cosavirus in a patient in the Mediterranean area. The patient was an adult double lung transplant recipient who had chronic diarrhea associated with persistent infection with human cosavirus.
In 2008, a new virus was detected in fecal samples from children with nonpolio acute flaccid paralysis (1). The genome structure of the new virus was closely related to those in the family Picornaviridae, but phylogenetic analysis showed that it diverged from known picornaviruses. Thus, a new genus of picornaviruses was proposed: Human Cosavirus (common stool-associated virus; HCoSV).
Prevalence of HCoSV varies according to patient age, geographic area, and exposure to enteric viruses in general; it has been identified in fecal samples of children with acute flaccid paralysis in Pakistan and Afghanistan, in healthy children, and in an adult patient in the United Kingdom (1). In a study by Kapoor et al., HCoSV strains were classified into 4 species (A, B, D, E). HCoSV was also found in a child with acute diarrhea in Australia (2) and, subsequently, was detected in China, Thailand, and Brazil. In China, 3.2% of hospitalized and 1.6% of healthy children were HCoSV positive, and all virus strains belonged to species A (3); in Thailand, HCoSV was detected in an adult patient but not in children with acute diarrhea (4); and in Brazil, the percentage of HCoV-positive symptomatic children (3.6%) was comparable to that reported in China; however, in 2 groups of asymptomatic children from whom samples were collected at different periods, HCoSV was detected in highly divergent percentages (6.5% vs. 49.2%) (5). In Brazil, HCoSV was also detected in an HIV-positive adult patient with acute gastroenteritis, and ≈75% of symptomatic HCoSV-positive patients were co-infected with other gastroenteric viruses. Kapusinszky et al. recently conducted phylogenetic analysis of viral protein (VP) 3–VP1 genes, which revealed greater genetic variability of HCoSV strains, and proposed splitting species A into 24 species (A1–A24), D into 5 species (D1–D5), E into 2 species (E1–E2), and classifying F as 1 species (6).
We report a case of HCoSV infection in an immunocompromised woman in northern Italy and the results of retrospective HCoSV testing of 689 stored fecal samples from hospitalized patients with gastrointestinal signs and symptoms. The study was performed according to guidelines of the institutional review board of the Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico, San Matteo, Pavia, Italy, on the use of biological specimens for scientific purposes in keeping with Italian law (Article 13 D.Lgs 196/2003) and after having obtained written informed consent from the patient.

No hay comentarios:

Publicar un comentario