日本語要約
Genomics: Comparisons across cancers
- Journal name:
- Nature
- Volume:
- 502,
- Pages:
- 306–307
- Date published:
- DOI:
- doi:10.1038/502306a
- Published online
Analysis of cancer genomes is moving beyond the confines of a particular disease — researchers are now comparing the genetic and epigenetic characteristics of multiple tumour types. Two scientists comment on what such studies can teach us about cancer biology and how they may guide clinical practice. See Article p.333
The paper in brief
- Research networks around the world are cataloguing DNA mutations, chemical changes to DNA-associated proteins, and expression of RNA transcripts and proteins in thousands of human tumours.
- In a series of 16 papers1, one of which is published on page 333 of this issue (Kandoth et al.)2, The Cancer Genome Atlas (TCGA) Research Network presents comparisons of such data across as many as 12 tumour types (Fig. 1).
- The publications join other pan-cancer efforts in revealing commonalities between all cancer types, shared molecular abnormalities in tumours that superficially seem distinct, and mutations that are confined to specific tumours.
- The findings will guide the development of prognostic, diagnostic and therapeutic strategies.
The Cancer Genome Atlas Research Network has presented a series1 of initial findings from comparisons of the tumour characteristics and clinical data of thousands of patients, covering 12 major types of cancer.
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