domingo, 20 de octubre de 2013

Going with the Flow: From Circulating Tumor Cells to DNA

Going with the Flow: From Circulating Tumor Cells to DNA

Sci Transl Med
Vol. 5, Issue 207, p. 207ps14
Sci. Transl. Med. DOI: 10.1126/scitranslmed.3006305


  • Perspective


CANCER BIOMARKERS


Going with the Flow: From Circulating Tumor Cells to DNA






  1. Jorge S. Reis-Filho1,



+ Author Affiliations



  1. 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.



  2. 2Department of Medical Oncology, Institut Curie, 75005 Paris, France.



  3. *These authors contributed equally to this work.




  1. Corresponding author. E-mail: reisfilj@mskcc.org





AbstractBack to Top



Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.






Citation: F.-C. Bidard, B. Weigelt, J. S. Reis-Filho, Going with the Flow: From Circulating Tumor Cells to DNA. Sci. Transl. Med. 5, 207ps14 (2013).




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