Nature TCGA | TCGA Pan-Cancer Analysis

Nature TCGA | TCGA Pan-Cancer Analysis

Focus on pan-cancer analysis

Genomic alterations in diverse cell types at different sites in the body give rise to hundreds of different forms of cancer, and the ways in which these changes result in tumors with different biology, pathology and treatment strategies are beginning to be characterized. The TCGA Research Network has catalogued aberrations in the DNA, chromatin and RNA of the genomes of thousands of tumors relative to matched normal cellular genomes and has analyzed their epigenetic and protein consequences. Here the Pan-Cancer initiative examines the similarities and differences among the genomic and cellular alterations found in the first dozen tumor types to be profiled by TCGA. This first look across cancer types offers new tools in genomics and bioinformatics and the prospect of repurposing targeted therapies directed by the molecular pathology of the tumors in addition to their clinical classification.

 

Foreword

Focus on pan-cancer analysis

Genomic alterations in diverse cell types at different sites in the body give rise to hundreds of different forms of cancer, and the ways in which these changes result in tumors with different biology, pathology and treatment strategies are beginning to be characterized. The TCGA Research Network has catalogued aberrations in the DNA, chromatin and RNA of the genomes of thousands of tumors relative to matched normal cellular genomes and has analyzed their epigenetic and protein consequences. Here the Pan-Cancer initiative examines the similarities and differences among the genomic and cellular alterations found in the first dozen tumor types to be profiled by TCGA. This first look across cancer types offers new tools in genomics and bioinformatics and the prospect of repurposing targeted therapies directed by the molecular pathology of the tumors in addition to their clinical classification.

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Mutational Drivers Network models Environmental exposure and pathogens Data discovery, transparency and visualization Future directions

Research Articles

The Cancer Genome Atlas Pan-Cancer analysis project

The Cancer Genome Atlas Research Network et al.

Emerging landscape of oncogenic signatures across human cancers

Giovanni Ciriello et al.

Pan-cancer patterns of somatic copy number alteration

Travis Zack, Steven Schumacher et al.

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael Lawrence, Peter Stojanov, Paz Polak et al.

Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth, Michael McLellan et al.

The landscape of viral expression and host gene fusion and adaptation in human cancer

Ka-Wei Tang et al.

Inferring tumor purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

Analysis of microRNA-target interactions across diverse cancer types

Anders Jacobsen et al.

TCPA: a resource for cancer functional proteomics data

Jun Li, Yiling Lu et al.

The mutational landscape of phosphorylation signaling in cancer

Jüri Reimand et al.

IntOGen-mutations identifies cancer drivers across tumor types

Abel Gonzalez-Perez et al.

Network-based stratification of tumor mutations

Matan Hofree et al.

Evidence for APOBEC3B mutagenesis in multiple human cancers

Michael Burns, Nuri Temiz & Reuben Harris

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

Steven Roberts et al.

Exploring TCGA Pan-Cancer Data at the UCSC Cancer Genomics Browser

Melissa Cline et al.

Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas

Larsson Omberg, Kyle Ellrott et al.

Comprehensive identification of mutational cancer driver genes across 12 tumor types

David Tamborero, Abel Gonzalez-Perez et al.

Additional Articles

News and Views: Comparisons across cancers

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Integrated genomic analyses of ovarian carcinoma

Comprehensive molecular characterization of human colon and rectal cancer

Comprehensive genomic characterization of squamous cell lung cancers

Comprehensive molecular portraits of human breast tumours

Integrated genomic characterization of endometrial carcinoma

Comprehensive molecular characterization of clear cell renal cell carcinoma

The mutational landscape of chromatin regulatory factors across 4623 tumor samples