Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

Francois-Pierre J. Martin mail,
Ivan Montoliu,
Sebastiano Collino,
Max Scherer,
Philippe Guy,
Isabelle Tavazzi,
Anita Thorimbert,
Sofia Moco,
Megan P. Rothney,
David L. Ergun,
Maurice Beaumont,
Fiona Ginty,
Salah D. Qanadli,
[ ... ],
Serge Rezzi mail
, [ view all ]

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Formal Correction: This article has been formally corrected to address the following errors.

There was an error in the title of the article. The correct version of the title in the article is: Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Obese Women

The correct citation is: Martin F-PJ,... (read formal correction)

Abstract

Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25–45 y, BMI: 28–40 kg/m²) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44:6, PC-O 44:4, PC-O 42:4, PC-O 40:4, and PC-O 40:3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics.

Citation: Martin F-PJ, Montoliu I, Collino S, Scherer M, Guy P, et al. (2013) Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women. PLoS ONE 8(9): e73445. doi:10.1371/journal.pone.0073445
Editor: Antonio Moschetta, University of Bari & Consorzio Mario Negri Sud, Italy
Received: March 21, 2013; Accepted: July 23, 2013; Published: September 11, 2013
Copyright: © 2013 Martin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The authors have no support or funding to report.
Competing interests: Authors FPM, SC, MS, SM, PG, IT, AT, SR are employees of Nestlé Institute of Health Science SA. Authors IM, MB are employees of Nestec S.A. Authors MPR, DLE, FG are employees of GE. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.