The Cancer Genome Atlas Pan-Cancer analysis project : Nature Genetics : Nature Publishing Group

The Cancer Genome Atlas Pan-Cancer analysis project : Nature Genetics : Nature Publishing Group

Nature Genetics | Commentary Open

Focus on TCGA Pan-Cancer Analysis

Focus issue:

October 2013 Volume 45, No 10

• • Analysis
  • Commentaries
• • Contents
  • Editorial
  • Foreword

The Cancer Genome Atlas Pan-Cancer analysis project

• The Cancer Genome Atlas Research Network,
• John N Weinstein,
• Eric A Collisson,
• Gordon B Mills,
• Kenna R Mills Shaw,
• Brad A Ozenberger,
• Kyle Ellrott,
• Ilya Shmulevich,
• Chris Sander
• & Joshua M Stuart

• Affiliations
• Corresponding author

Nature Genetics

45,

1113–1120

(2013)

doi:10.1038/ng.2764

Published online

26 September 2013

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Abstract

• Abstract•
• References•
• Acknowledgments•
• Author information

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

At a glance

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Cancer can take hundreds of different forms depending on the location, cell of origin and spectrum of genomic alterations that promote oncogenesis and affect therapeutic response. Although many genomic events with direct phenotypic impact have been identified, much of the complex molecular landscape remains incompletely charted for most cancer lineages.