CIENCIASMEDICASNEWS: Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide, Journal of Asthma, Informa Healthcare

miércoles, 9 de octubre de 2013

Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide, Journal of Asthma, Informa Healthcare

Pediatric Asthma

Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide

March 2013, Vol. 50, No. 2 , Pages 162-165 (doi:10.3109/02770903.2012.754030)

Jose A. Castro-Rodriguez, M.D., PH.D.,^1,* Olaia Sardón, M.D., PH.D.,^2,³ Eduardo G. Pérez-Yarza, M.D., PH.D.,^2,³ Javier Korta, M.D., PH.D.,^2,³ Ane Aldasoro, M.D.,² Paula Corcuera, M.D.,² and Javier Mintegui, M.D.²

¹Division of Respiratory Medicine, Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile,

Santiago

, Chile

²Division of Respiratory Medicine, Department of Pediatrics, Hospital Universitario Donostia,

San Sebastián

, Spain

³Department of Pediatrics, School of Medicine, UPV/EHU,

San Sebastián

, Spain

*Corresponding author: Jose A. Castro-Rodríguez, M.D., Ph.D., Division of Respiratory Medicine, Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile,

Lira 44, 1er. Piso, casilla 114-D, Santiago

, Chile; Tel: (56)-2-354-8189; Fax: (56)-2-354-8122; E-mail: jacastro17@hotmail.com

Objective. The aim of this post hoc analysis was to establish the relationship between FE_NO levels and the asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants with recurrent wheezing (three or more episodes) were recruited consecutively and online FE_NO tests at tidal breathing with multiple breaths were performed. Results. Twenty-seven (84%) out of 32 infants (median age of 12 months) who met the inclusion criteria for this post hoc analysis, successfully performed the FE_NO determinations. Eighteen (66%) infants were classified with positive stringent API. FE_NO levels were significantly higher among patients with positive API than those with negative (median [IQR] of 12.3 [14.8] ppb vs. 4.1 [7.9] ppb, respectively, p = .016). Furthermore, FE_NO and positive API had a significant correlation (Spearman’s rho, ρ = 0.4741, p = .0125). After logistic regression analysis including FE_NO levels, gender, age, and use of controller therapy, FE_NO was the only variable that was marginally related to API (OR = 1.12, 95% CI: 0.99–1.27, p = .07). Conclusion. Infants with recurrent wheezing who had a positive stringent API already had higher FE_NO levels than those with a negative API. This finding needs to be corroborated in a larger prospective study.