Prioritizing Genomic Applications for Action by Level of Evidence: A Horizon-Scanning Method.

Dotson WD1, Douglas MP2, Kolor K1, Stewart AC2, Bowen MS1, Gwinn M2, Wulf A3, Anders HM2, Chang CQ4, Clyne M5, Lam TK4, Schully SD4, Marrone M6,Feero WG7, Khoury MJ8.

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Abstract

As evidence accumulates on the use of genomic tests and other health-related applications of genomic technologies, decision makers may increasingly seek support in identifying which applications have sufficiently robust evidence to suggest they might be considered for action. As an interim working process to provide such support, we developed a horizon-scanning method that assigns genomic applications to tiers defined by availability of synthesized evidence. We illustrate an application of the method to pharmacogenomics tests.Clinical Pharmacology & Therapeutics (2014); advance online publication 8 January 2014. doi:10.1038/clpt.2013.226.