Media Availability: Vaccine Made from Complex of Two Malaria Proteins Protects Mice From Lethal Infection

Media Availability: Vaccine Made from Complex of Two Malaria Proteins Protects Mice From Lethal Infection

Vaccine Made from Complex of Two Malaria Proteins Protects Mice from Lethal Infection

NIAID scientists have modified an experimental malaria vaccine that they originally developed more than a decade ago. The new vaccine features parts of two key malaria parasite proteins, AMA1 and RON2, which are delivered as a complex. In nature, malaria parasites use the AMA1-RON2 complex to invade red blood cells. The complex vaccine protected mice from a lethal form of malaria and a similar approach could be used in next-generation human vaccines. More information about the recent publication by investigators from NIAID’s Laboratory of Malaria and Vector Research is available here http://www.niaid.nih.gov/news/newsreleases/2014/Pages/MalariaProteinComplex.aspx