lunes, 2 de junio de 2014

Predictive factors of diabetic compl... [J Diabetes Metab Disord. 2014] - PubMed - NCBI

Predictive factors of diabetic compl... [J Diabetes Metab Disord. 2014] - PubMed - NCBI



 2014 May 8;13:55. doi: 10.1186/2251-6581-13-55. eCollection 2014.

Predictive factors of diabetic complications: a possible link between family history of diabetes and diabetic retinopathy.

Abstract

BACKGROUND:

The aim of this study was assessment of predictive factors of diabetic retinopathy.

METHODS:

A cross-sectional study was designed by recruiting 1228 type 2 diabetic patients from a diabetes referral clinic over a six-month period (from July to December, 2012). Diabetes risk factors, complications, laboratory results have been recorded.

RESULTS:

Of the 1228 diabetic patients (54% women, mean age 58.48 ± 9.94 years), prevalence of diabetes retinopathy was 26.6%. There were significant associations between retinopathy and family history of diabetes (p = 0.04), hypertension (p = 0.0001), diabetic duration (p = 0.0001), poor glycemic control (p = 0.0001) and age of onset of diabetes (p = 0.0001). However, no significant associations were found between retinopathy with dyslipidemia and obesity. In logistic regression model, poor glycemic control (p = 0.014), hypertension (p = 0.0001), duration of diabetes (p = 0.0001) and family history of diabetes (p = 0.012) independently predicted retinopathy after adjustment for age and sex.

CONCLUSIONS:

Diabetic complications are resulting from an interaction from genes and environmental factors. A family history of diabetes is pointing toward a possible genetic and epigenetic basis for diabetic retinopathy. Our findings suggest the role of epigenetic modifications and metabolic memory in diabetic retinopathy in subjects with family history of diabetes.

KEYWORDS:

Diabetic retinopathy; Epigenetic; Family history of diabetes

PMID:
 
24860795
 
[PubMed] 
PMCID:
 
PMC4031909
 
Free PMC Article

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