lunes, 26 de enero de 2015

Mosquito genomics. Highly evolvable malaria vectors: the genomes of... - PubMed - NCBI

Mosquito genomics. Highly evolvable malaria vectors: the genomes of... - PubMed - NCBI



 2015 Jan 2;347(6217):1258522. doi: 10.1126/science.1258522. Epub 2014 Nov 27.

Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

Neafsey DE1Waterhouse RM2Abai MR3Aganezov SS4Alekseyev MA4Allen JE5Amon J6Arcà B7Arensburger P8Artemov G9Assour LA10Basseri H3Berlin A11Birren BW11Blandin SA12Brockman AI13Burkot TR14Burt A15Chan CS16Chauve C17Chiu JC18Christensen M5Costantini C19,Davidson VL20Deligianni E21Dottorini T13Dritsou V22Gabriel SB23Guelbeogo WM24Hall AB25Han MV26Hlaing T27Hughes DS28Jenkins AM29,Jiang X30Jungreis I16Kakani EG31Kamali M32Kemppainen P33Kennedy RC34Kirmitzoglou IK35Koekemoer LL36Laban N37Langridge N5Lawniczak MK13Lirakis M38Lobo NF39Lowy E5MacCallum RM13Mao C40Maslen G5Mbogo C41McCarthy J8Michel K20Mitchell SN42Moore W43Murphy KA18Naumenko AN32Nolan T13Novoa EM16O'Loughlin S15Oringanje C43Oshaghi MA3Pakpour N44Papathanos PA45Peery AN32Povelones M46,Prakash A47Price DP48Rajaraman A17Reimer LJ49Rinker DC50Rokas A51Russell TL14Sagnon N24Sharakhova MV32Shea T11Simão FA52,Simard F19Slotman MA53Somboon P54Stegniy V9Struchiner CJ55Thomas GW56Tojo M57Topalis P21Tubio JM58Unger MF39Vontas J38Walton C33Wilding CS59Willis JH60Wu YC61Yan G62Zdobnov EM52Zhou X63Catteruccia F31Christophides GK13Collins FH39Cornman RS60Crisanti A45,Donnelly MJ64Emrich SJ10Fontaine MC65Gelbart W66Hahn MW67Hansen IA48Howell PI68Kafatos FC13Kellis M16Lawson D5Louis C69Luckhart S44Muskavitch MA70Ribeiro JM71Riehle MA43Sharakhov IV72Tu Z73Zwiebel LJ74Besansky NJ75.

Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
Copyright © 2015, American Association for the Advancement of Science.

PMID:
 
25554792
 
[PubMed - indexed for MEDLINE]

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