domingo, 22 de febrero de 2015

Milestones of Lynch syndrome: 1895-2015. - PubMed - NCBI

Milestones of Lynch syndrome: 1895-2015. - PubMed - NCBI



 2015 Feb 12. doi: 10.1038/nrc3878. [Epub ahead of print]

Milestones of Lynch syndrome: 1895-2015.

Abstract

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.

PMID:
 
25673086
 
[PubMed - as supplied by publisher]

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