Infertility: Genomic Insights - April 20, 2015

Genomics|Features|Infertility

Infertility: Genomic Insights - April 20, 2015

CDC and Related Info

• What is assisted reproductive technology?
• Infertility frequently asked questions
• Genes reported in relation to infertility, including genomewide association studies via theHuGE Navigator

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases.
Tarín JJ et al. Reprod. Biol. Endocrinol. 2015 Apr 15. (1) 31

Mutation analysis in patients with total sperm immotility.
Pereira R et al. J. Assist. Reprod. Genet. 2015 Apr 16.

Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men.
Chihara M et al. J. Assist. Reprod. Genet. 2015 Apr 7.

Cost-effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss.
Murugappan G et al. Fertil. Steril. 2015 Mar 12.

Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Li Z et al. Sci Rep 2015 8785

Counseling and diagnostic evaluation for the infertile couple.
Marshburn PB et al. Obstet. Gynecol. Clin. North Am. 2015 Mar (1) 1-14

Polymorphisms in inhibin α gene promoter associated with male infertility.
Li WH et al. Gene 2015 Apr 1. (2) 172-6

Infertility, Assisted Reproductive Technology and Genomics - January 12, 2015

Safety of assisted reproductive technology in the United States, 2000-2011
Jennifer F. Kawwass et al. JAMA, January 7, 2015

Assisted reproductive technology has low complication risk, US data show.
BMJ 2015; 350 (January 7, 2015)

Recent Genomic Insights

Polar bodies in assisted reproductive technology: Current progress and future perspectives.
Wei Y, et al. Biol Reprod. 2014 Dec 3.

OMICS: Current and future perspectives in reproductive medicine and technology.
Egea RR, et al. J Hum Reprod Sci. 2014 Apr;7(2):73-92

Toward the identification of a subset of unexplained infertility: a sperm proteomic approach.
McReynolds S, et al.  Fertil Steril. 2014 Sep;102(3):692-9

Epigenetic effects on the embryo as a result of periconceptional environment and assisted reproduction technology.
Lucas E. Reprod Biomed Online. 2013 Nov;27(5):477-85.

Infertility: The Role of Genetics - July 15, 2014

CDC information: Infertility frequently asked questions

CDC information: What is assisted reproductive technology?

Did you know? 443 genes have reported in relation to risks and outcomes of infertility, including 16 genomewide association studies? To find out more, visit the HuGE Navigator

Find out about genetic disorders and tests associated with infertility, NIH Genetic Testing Registry

Infertility: Tests and diagnosis, Mayo Clinic (2013) 

Multicentre study of the clinical relevance of screening IVF patients for carrier status of the annexin A5 M2 haplotype.
Simon Fishel et al. Reproductive Medicine Online, July 2014  

Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy
Harper J, et al. Hum Reprod 2014 Aug;29(8):1603-9

Genetic screening could reduce recurrent miscarriages, PHG Foundation, Jul 2

Fertility clinics scan for the strongest embryo, by Andrew Pollack, New York Times, Jul 11