Meningococcal Disease, Vaccines and Genomics - April 21, 2015

Genomics|Features|Meningococcal Disease

Meningococcal Disease

Meningococcal Disease, Vaccines and Genomics - April 21, 2015

CDC and Related Info

• Meningococcal disease
• Preteens, teens need Meningococcal vaccine
• Genes reported in relation to risk of meningococcal meningitis, including genomewide association studies via theHuGE Navigator

CDC information:Meningococcal disease

Preteens, teens need Meningococcal vaccine

Find out what genes have been reported in relation to risk of meningococcal meningitis, from the HuGE Navigator

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Owen EP et al. Mol. Immunol. 2015 Mar (1) 170-6

Genetic susceptibility to meningococcal infection.
Dale AP et al. Expert Rev Anti Infect Ther 2013 Feb (2) 187-99

Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis.
Brouwer MC et al. Lancet Infect Dis 2010 Apr (4) 262-74

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility.
Caesar JJ et al. Elife 2014

A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes.
Bratcher HB et al. BMC Genomics 2014 1138

Genetic diversity and levels of expression of factor H binding protein among carriage isolates of Neisseria meningitidis.
Lemée L et al. PLoS ONE 2014 (9) e107240

nspA gene as a specific genetic marker for detection of Neisseria meningitidis causing bacterial meningitis.
Bhatt N et al. Indian J. Biochem. Biophys. 2014 Jun (3) 211-4

Prognostic markers of pediatric meningococcal sepsis.
Briassoulis G et al. Expert Rev Anti Infect Ther 2014 Sep (9) 1017-20

Draft genome sequence of C:P1.5-1,10-8:F3-6:ST-11 meningococcal clinical isolate associated with a cluster on a cruise ship.
Neri A et al. Genome Announc 2014 (6)