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Acute Middle East Respiratory Syndrome Coronavirus Infection in Livestock Dromedaries, Dubai, 2014 - Volume 21, Number 6—June 2015 - Emerging Infectious Disease journal - CDC

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Acute Middle East Respiratory Syndrome Coronavirus Infection in Livestock Dromedaries, Dubai, 2014 - Volume 21, Number 6—June 2015 - Emerging Infectious Disease journal - CDC





Volume 21, Number 6—June 2015

Dispatch

Acute Middle East Respiratory Syndrome Coronavirus Infection in Livestock Dromedaries, Dubai, 2014

Ulrich WerneryComments to Author , Victor M. Corman, Emily Y.M. Wong, Alan K.L. Tsang, Doreen Muth, Susanna K. P. Lau, Kamal Khazanehdari, Florian Zirkel, Mansoor Ali, Peter Nagy, Jutka Juhasz, Renate Wernery, Sunitha Joseph, Ginu Syriac, Shyna K. Elizabeth, Nissy Annie Georgy Patteril, Patrick C. Y. Woo, and Christian Drosten
Author affiliations: Central Veterinary Research Laboratory, Dubai, United Arab Emirates (U. Wernery, K. Khazanehdari, R. Wernery, S. Joseph, G. Syriac, S.K. Elizabeth, N.A. Georgy Patteril)University of Bonn Medical Centre, Bonn, Germany (V.M. Corman, F. Zirkel, C. Drosten); German Centre for Infection Research, Bonn (V.M. Corman, F. Zirkel, C. Drosten)University of Hong Kong, China (E.Y.M. Wong, A.K.L. Tsang, D. Muth, S.K.P. Lau, P.C.Y. Woo)Dubai Camel Hospital, Dubai (M. Ali)Emirates Industry for Camel Milk and Products, Dubai (P. Nagy, J. Juhasz)

Abstract

Camels carry Middle East respiratory syndrome coronavirus, but little is known about infection age or prevalence. We studied >800 dromedaries of all ages and 15 mother–calf pairs. This syndrome constitutes an acute, epidemic, and time-limited infection in camels <4 years of age, particularly calves. Delayed social separation of calves might reduce human infection risk.
Middle East respiratory syndrome coronavirus (MERS-CoV) causes outbreaks and isolated cases of severe respiratory disease in humans. The virus is transmissible from human to human, but the focus of infection has remained in countries on the Arabian Peninsula. Recent reports have shown that dromedaries (Camelus dromedarius) across the Arabian Peninsula and parts of eastern and northern Africa have MERS-CoV antibodies (14). Virus detection by reverse transcription PCR (RT-PCR) and sequencing has confirmed that these antibodies are likely to be caused by infection with the same virus strains that infect humans (5). In singular cases, strong evidence for virus transmission between camels and humans was found (6,7). Infection of dromedaries in the laboratory has confirmed susceptibility and efficient shedding (8). MERS-CoV antibodies were not found in other species of livestock and leisure animals, including cattle, goats, sheep, and horses (9).
In the absence of a MERS-CoV vaccine, the prevention of human infections relies on knowledge of acute infection in camels. Available serologic studies indicate a high prevalence of MERS-CoV in adult camels, suggesting that MERS-CoV infection in camels may target young animals (14). However, only limited data on the age of animals at infection and the degree of age-specificity are available (5).
To best approximate the actual infectivity of virus in camels, testing should include RT-PCR and systematic virus isolation in cell culture (10). We recently analyzed a small group of camels in Saudi Arabia and found signs of recent acute MERS-CoV infection by demonstrating seroconversion, indicating a method for the serologic diagnosis of acute infection (7). To increase knowledge of acute MERS-CoV in dromedaries, we analyzed acute- and convalescent-phase MERS-CoV infections in similarly sized groups of camels of the same age in Dubai, United Arab Emirates.

Dr. Wernery, a veterinary microbiologist, is head of the Central Veterinary Research Laboratory in Dubai, United Arab Emirates. His main research interest is infectious diseases of livestock, in particular camels, of the Arabian Peninsula.

Acknowledgments


We thank Monika Eschbach-Bludau, Sebastian Brünink, Tobias Bleicker, and Artem Siemens for excellent technical assistance.
This work was partly supported by the Seed Funding for Theme-Based Research Scheme and Strategic Research Theme Fund, The University of Hong Kong; Research Grant Council Grant, University Grant Council; and Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease of the Hong Kong Special Administrative Region Department of Health. Work in Bonn was funded by the European Commission ANTIGONE (Anticipating the Global Onset of Novel Epidemics) project (contract no. 278976) and the Deutsche Forschungsgemeinschaft (grant DR 772/7-1 to C.D.).

References

  1. Reusken CBMessadi LFeyisa AUlaramu HGodeke GJDanmarwa AGeographic distribution of MERS coronavirus among dromedary camels, Africa. Emerg Infect Dis2014;20:13704DOIPubMed
  2. Meyer BMuller MACorman VMReusken CBRitz DGodeke GJAntibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013. Emerg Infect Dis2014;20:5529DOIPubMed
  3. Reusken CBHaagmans BLMuller MAGutierrez CGodeke GJMeyer BMiddle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis2013;13:85966DOIPubMed
  4. Müller MACorman VMJores JMeyer BYounan MLiljander AMERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983–1997.Emerg Infect Dis2014;20:20935DOIPubMed
  5. Alagaili ANBriese TMishra NKapoor VSameroff SCBurbelo PDMiddle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio2014;5:e0088414DOIPubMed
  6. Haagmans BLAl Dhahiry SHReusken CBRaj VSGaliano MMyers RMiddle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis2014;14:1405DOIPubMed
  7. Memish ZACotten MMeyer BWatson SJAlsahafi AJAl Rabeeah AAHuman Infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg Infect Dis2014;20:10125 . DOIPubMed
  8. Adney DRvan Doremalen NBrown VRBushmaker TScott Dde Wit EReplication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis2014;20:19992005DOIPubMed
  9. Reusken CBAbabneh MRaj VSMeyer BEljarah AAbutarbush SMiddle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013. Euro Surveill2013;18:20662 .PubMed
  10. Raj VSFarag EAReusken CBLamers MMPas SDVoermans JIsolation of MERS coronavirus from a dromedary camel, Qatar, 2014. Emerg Infect Dis2014;20:133942DOIPubMed
  11. Drosten CMeyer BMuller MACorman VMAl-Masri MHossain RTransmission of MERS-coronavirus in household contacts. N Engl J Med.2014;371:82835DOIPubMed
  12. Corman VMJores JMeyer BYounan MLiljander ASaid MYAntibodies against MERS coronavirus in dromedary camels, Kenya, 1992–2013.Emerg Infect Dis2014;20:131922DOIPubMed
  13. Corman VMEckerle IBleicker TZaki ALandt OEschbach-Bludau MDetection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill2012;17:20285 .PubMed
  14. Drosten CMuth DCorman VMHussain RAl Masri MHajomar WAn observational, laboratory-based study of outbreaks of MERS-coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014. Clin Infect Dis2015;60:36977 .PubMed
  15. Hemida MGChu DKPoon LLPerera RAAlhammadi MANg HYMERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis.2014;20:12314DOIPubMed

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Suggested citation for this article: Wernery U, Corman VM, Wong EYM, Tsang AKL, Muth D, Lau SKP, et al. Acute Middle East respiratory syndrome coronavirus infection in livestock dromedaries, Dubai, 2014. Emerg Infect Dis. 2015 Jun [date cited]. http://dx.doi.org/10.3201/eid2106.150038
DOI: 10.3201/eid2106.150038

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