domingo, 17 de mayo de 2015

Two susceptibility loci identified for prostate cancer aggressiveness. - PubMed - NCBI

Two susceptibility loci identified for prostate cancer aggressiveness. - PubMed - NCBI



 2015 May 5;6:6889. doi: 10.1038/ncomms7889.

Two susceptibility loci identified for prostate cancer aggressiveness.

Abstract

Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49 × 10(-9)) and rs78943174 at 3q26.31 (NAALADL2, P=4.18 × 10(-8)). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85 × 10(-5)) with no association for nonaggressive prostate cancer compared with controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation.

PMID:
 
25939597
 
[PubMed - in process] 
PMCID:
 
PMC4422072
 [Available on 2015-11-05]

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