The Placenta: Genomic Insights - June 18, 2015

Genomics|Features|Placenta

Placenta

The Placenta: Genomic Insights - June 18, 2015

Researchers design placenta-on-a-chip to better understand pregnancy, NIH News, June 18, 2015

Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.
Eidem HR et al. BMC Med Genomics 2015 27

Environmental influences on genomic imprinting.
Kappil M et al. Curr Environ Health Rep 2015 Jun (2) 155-162

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study.
Janssen BG et al. Epigenetics 2015 Jun 3. (6) 536-44

DNA methylation changes in the placenta are associated with fetal manganese exposure.
Maccani JZ et al. Reprod. Toxicol. 2015 May 15.

Evaluating intra- and inter-individual variation in the human placental transcriptome.
Hughes DA et al. Genome Biol. 2015 54

The perinatal microbiome and pregnancy: Moving beyond the vaginal microbiome.
Prince AL et al. Cold Spring Harb Perspect Med 2015 (6)

MicroRNAome in decidua: a new approach to assess the maintenance of pregnancy.
Wang Y et al. Fertil. Steril. 2015 Apr (4) 980-989.e6

Identification of early transcriptome signatures in placenta exposed to insulin and obesity.
Lassance L et al. Am. J. Obstet. Gynecol. 2015 May (5) 647.e1-647.e11

The Human Placenta Project - March 16, 2015

Q&A with Human Placenta Project Coordinator, National Institute for Child Health and Dwevelopment, March 2015

NIH invests US$41.5 million in placenta research US agency launches project aimed at monitoring organ in real time , by Sara Reardon, Nature News, Feb 27

NIH announces $41.5 million in funding for the Human Placenta Project (Feb 26)
Better understanding of the placenta promises to improve the health of mothers and children

The Human Placenta Project website, from the National Institute for Child Health and Development

Request for Information (RFI): An internet resource for placental research - Placental Atlas Tool, NIH, Feb 25

Invigorating placental research through the "Human Placenta Project".
Sadovsky Y et al. Placenta 2014 Aug (8) 527

The Human Placenta Project: Placental structure, development, and function in real time.
Guttmacher A E et al. Placenta 2014 May (5) 303-4

The role and interaction of imprinted genes in human fetal growth.
Moore Gudrun E et al. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2015 Mar 5. (1663)

Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta.
Vilahur Nadia et al. Environ Int 2014 Oct 81-7

The placenta harbors a unique microbiome.
Aagaard Kjersti et al. Sci Transl Med 2014 May 21. (237) 237ra65

The Placenta: Genomics & Health - July 31, 2014

The mysterious tree of a newborn's life. The push to understand the placenta, by Denise Grady, New York Times, Jul 14

The Human Placenta Project: Placental structure and function in real time. National Institute of Child Health and Development, workshop, May 2014 

NIH's Human Placenta Project is validation for placental cells curing deadly diseases,
Sharon DiStefano, Jul. 10, 2014 

Recent Selected Placenta Genomics Articles

Copy number variation is a fundamental aspect of the placental genome
Roberta L. Hannibal, et al. PLOS Genetics, May 2014

Comprehensive genome-wide proteomic analysis of human placental tissue for the Chromosome-Centric Human Proteome Project.
Lee HJ et al. , J Proteome Res. 2013 Jun 7;12(6):2458-66.

Paternally expressed genes predominate in the placenta.
Wang X et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10705-10.

The human placenta methylome.
Schroeder DI et al. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6037-42.