Type 1 Diabetes: Genetics and Public Health - July 14, 2015

Genomics|Features|Diabetes Type 1

Diabetes: Type 1

Type 1 Diabetes: Genetics and Public Health - July 14, 2015

CDC and Related Info

• Diabetes basics, types 1 and 2
• Genes reported in relation to type 1 diabetes, including genomewide association studies via theHuGE Navigator

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Hu X et al, Nature Genetics, July 13, 2015

HLA-DQ genotypes - but not immune markers - differ by ethnicity in patients with childhood onset type 1 diabetes residing in Belgium.
Stoupa A et al. Pediatr Diabetes 2015 Jul 1.

Association of HLA-DQA1 and -DQB1 alleles with type I diabetes in Arabs: a meta-analyses.
Hamzeh AR et al. Tissue Antigens 2015 Jul (1) 21-7

HLA-DQ genetic risk gradient for type 1 diabetes and celiac disease in north-western Mexico.
Mejía-León ME et al. Rev Gastroenterol Mex 2015 Jun 16.

What is type 1 diabetes? Medline Plus, National Library of Medicine

CDC information: Diabetes basics, types 1 and 2

Check out genes reported in relation to risk of type 1 diabetes, from the HuGE Navigator

Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes
Ezio B et al, JAMA, April 21, 2015

Environmental trigger(s) of type 1 diabetes: Why so difficult to identify?
Rønningen KS et al. Biomed Res Int 2015 321656

Role of nutritional factors at the early life stages in the pathogenesis and clinical course of type 1 diabetes.
Kagohashi Y et al. Biomed Res Int 2015 382165

Luminex and other multiplex high throughput technologies for the identification of, and host response to, environmental triggers of type 1 diabetes.
Purohit S et al. Biomed Res Int 2015 326918

Global epidemiology of type 1 diabetes in young adults and adults: a systematic review.
Diaz-Valencia PA et al. BMC Public Health 2015 (1) 255

Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research.
Graham ML et al. Eur. J. Pharmacol. 2015 Mar 24.

Differential gene expression in diabetic nephropathy in individuals with type 1 diabetes.
Caramori ML et al. J. Clin. Endocrinol. Metab. 2015 Apr 14. jc20144465

Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes.
Brorsson CA et al. Diabetes 2015 Mar 31.

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Onengut-Gumuscu S et al. Nat. Genet. 2015 Apr (4) 381-6

Immunogenetics of type 1 diabetes mellitus.
Morran MP et al. Mol. Aspects Med. 2015 Apr 42-60