domingo, 2 de agosto de 2015

TNF Receptors Predict Incident Hip Fracture Risk in the WHI Study and Fatty Acid Intake Does Not Modify this Association. - PubMed - NCBI

TNF Receptors Predict Incident Hip Fracture Risk in the WHI Study and Fatty Acid Intake Does Not Modify this Association. - PubMed - NCBI



 2015 Jul 10:JC20151662. [Epub ahead of print]

TNF Receptors Predict Incident Hip Fracture Risk in the WHI Study and Fatty Acid Intake Does Not Modify this Association.

Abstract

CONTEXT:

Chronic inflammation may increase risk of fracture and omega-3 polyunsaturated fatty acids (PUFA) may reduce fracture risk via down regulation of inflammatory cytokine gene expression and other mechanisms.

OBJECTIVE:

We investigated associations between baseline samples of inflammatory markers, tumor necrosis factor α soluble receptors 1 and 2 (TNFα-sR1 and sR2) and incident hip fracture. These associations were then tested for effect modification by dietary PUFA intake estimated by baseline food frequency questionnaire.

DESIGN AND SETTING:

A nested case-control study was conducted among participants of the Women's Health Initiative Observational Study (ages 50-79). Multivariable conditional logistic regression models were constructed to account for the paired design.

PARTICIPANTS:

This study sampled 400 pairs of hip fracture cases and controls without incident hip fracture, matched on age, year of enrollment, and menopausal hormone use.

MAIN OUTCOME MEASURES:

Odds ratio (OR) of hip fracture by quartile of TNF soluble receptors Results: OR of hip fracture comparing the highest to lowest quartile was 2.24 (95% confidence interval [CI], 1.05-4.79; p for linear trend 0.048) for TNFα-sR1 and 2.83 (95% CI, 1.34-5.99; p for linear trend 0.011) for TNFα-sR2, adjusted for FRAX hip fracture score, nutritional variables and selected factors impacting inflammation; there was a gradient of risk by increasing quartile in TNFα-sR1. PUFA intake did not modify these associations.

CONCLUSIONS:

Women with the highest levels of TNFα-sR1 and TNFα-sR2 had greater than two-fold increased hip fracture risk, independent of other fracture risk factors. These associations did not differ by high versus low PUFA intake.

PMID:
 
26161450
 
[PubMed - as supplied by publisher]

No hay comentarios:

Publicar un comentario