Diabetes: Recent Genomic Insights - September 8, 2015

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Diabetes: Type 2

Diabetes: Recent Genomic Insights - September 8, 2015

CDC and Related Info

• Prediabetes and risk factors
• Prevent type 2 diabetes
• Will diabetes be part of your story?
• Does diabetes run in your family? Take steps towards better health!
• Check your knowledge: diabetes and pregnancy
• Diabetes Latest
• Prediabetes: Am I at risk?
• Living with diabetes: Keep your feet healthy
• Genes reported in relation to diabetes, including genomewide association studies via theHuGE Navigator

Prevalence of and trends in diabetes among adults in the United States, 1988-2012

Menke A et al. JAMA, September 8, 2015

Diabetes advances in diagnosis and treatment

DM Nathan, JAMA, September 8, 2015

An islet-targeted genome-wide association scan identifies novel genes implicated in cytokine-mediated islet stress in type 2 diabetes.

Sharma PR et al. Endocrinology 2015 May 27. en20151203

Towards a genotype-based approach for a patient-centered pharmacologic therapy of type 2 diabetes.

Scheen AJ et al. Ann Transl Med 2015 May (Suppl 1) S36

Screening for type 2 diabetes mellitus: A systematic review for the U.S. Preventive Services Task Force 

Selph S et al. Annals of Internal Medicine, April 14, 2015

Genetics: Epigenetic mechanisms underlying type 2 diabetes mellitus.

Hanson MA et al. Nat Rev Endocrinol 2015 May (5) 261-263

Screening for hyperglycemia: The gateway to diabetes prevention and management for all Americans

Venkat Narayan et al. Annals of Internal Medicine, April 14, 2015

Understanding type 2 diabetes: from genetics to epigenetics.

Raciti GA et al. Acta Diabetol 2015 Apr 5.

The genetics of diabetic complications.

Ahlqvist E et al. Nat Rev Nephrol 2015 Mar 31.

Patient beliefs and behaviors about genomic risk for type 2 diabetes: implications for prevention.

Gallagher P et al. J Health Commun 2015 Apr 6. 1-8

Genetics of type 2 diabetes-pitfalls and possibilities.

Prasad RB et al. Genes (Basel) 2015 (1) 87-123

Hispanic Americans living in the United States and their risk for obesity, diabetes and kidney disease: Genetic and environmental considerations.

Yracheta JM et al. Postgrad Med 2015 Mar 7. 1-8

Metabolomics and diabetes: analytical and computational approaches.

Sas KM et al. Diabetes 2015 Mar (3) 718-32

Integrated genomic and BMI analysis for type 2 diabetes risk assessment.

Lebrón-Aldea D et al. Front Genet 2015 75

The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for Type 2 diabetes.

Walford GA et al. PLoS ONE 2015 (3) e0121553

The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.

Harder MN et al. PLoS ONE 2015 (3) e0120890

Prediabetes: Public Health and Genomic Insights - March 12, 2015

Are you screening for prediabetes? Prevent diabetes STAT, tool kit from the American Medical Association and the Centers for Disease Control and Prevention

Download Prevent Diabetes STAT tool kit

Screen, Test, Act, Today

CDC information: Prediabetes and risk factors 

Risk factors include family health history

Risk assessment tools for detecting those with pre-diabetes: a systematic review.

Barber SR et al. Diabetes Res. Clin. Pract. 2014 Jul (1) 1-13

The personalized approach for detecting prediabetes and diabetes.

Dankner R et al. Curr Diabetes Rev 2015 Jan 9.

Family awareness. Monitoring diabetes risk.

Hieronymus L et al. Diabetes Self Manag 2014 Jul-Aug (4) 22-4, 26

Find out which genes have been reported in relation to prediabetes, from the HuGE Navigator

Prevent Type 2 Diabetes: Insights from Family Health History and Genomics - February 9, 2015

CDC information: Prevent or delay type 2 diabetes by learning your risk factors, eating right, becoming more physically active, losing a modest amount of weight, and managing stress. You can make a healthy change today

Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.

Johansen Taber KA, et al. Appl Clin Genet. 2015 Jan 7;8:1-8.

Rare and common genetic events in type 2 diabetes: What should biologists know?

Bonnefond A, et al. Cell Metab. 2015 Jan 27. pii:

Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.

Berná G, et al. Nutrients. 2014 Nov 21;6(11):5338-69

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Wessel J. et al. Nat Commun. 2015 Jan 29;6:5897

Type 2 Diabetes: Family Health History and Genetics - November 13, 2014

CDC feature: Will diabetes be part of your story? Know your risk for diabetes and see if it could be a part of your story

National Diabetes Education Program Video:  Preventing Type 2 Diabetes: Maintaining a healthy weight. Losing weight wasn't easy for Latecia, but after seeing her mom live with diabetes, she knew she needed to make changes in her life to prevent the disease

Does diabetes run in your family? Take steps towards better health!

Recent Insights

Susceptibility to type 2 diabetes mellitus—from genes to prevention.

Marie-France Hivert et al. Nature Reviews Endocrinology 2014;10:198-205

Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.

Basile KJ, et al. Curr Diab Rep. 2014 Nov;14(11):550.

Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.

Vaag A, et al. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108

Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus.

Banerjee M, et al. World J Diabetes. 2014 Aug 15;5(4):493-504.

Metformin pharmacogenomics: current status and future directions.

Pawlyk AC, et al. Diabetes. 2014 Aug;63(8):2590-9.

Diabetes & Pregnancy: Role of Genetics and Family Health History - November 6, 2014

CDC information: November is Diabetes Awareness Month. How much do you know about diabetes during pregnancy? Check your knowledge

From the National Diabetes Education Program: Family Health History and Diabetes- If you are a woman who had gestational diabetes during pregnancy, you are at increased risk for developing diabetes, and the child of that pregnancy is at increased risk for obesity and type 2 diabetes

From Medline & NLM Reference: You are at greater risk for gestational diabetes if you have a family health history of diabetes

Did you know? 264 genes have been reported in relation to risk and outcomes of gestational diabetes, including 2 genomewide association studies. To find out more, visit the HuGE Navigator

Recent Insights

Obesity and diabetes: from genetics to epigenetics.

Burgio E, et al. Mol Biol Rep. 2014 Sep 25

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

Quilter CR, et al. FASEB J. 2014 Nov;28(11):4868-79

Genetic counseling for diabetes mellitus.

Stein SA, et al. Curr Genet Med Rep. 2014 Jun 1;2(2):56-67.

Diabetes Prevention: Family Health History and Genetics - September 11, 2014

Recommendation from the Task Force on Community Preventive Services (2014) Diabetes Prevention and Control: Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among People at Increased Risk

CDC information: More than 29 million Americans have diabetes; 1 in 4 doesn't know

If you have a mom, dad, brother or sister with type 2 diabetes you have a greater chance of getting the disease, the National Diabetes Education Program

CDC information: Prediabetes: Am I at risk?

Did you know? More than 3400 genes have been reported with risk of type 2 diabetes and its outcomes, including more than 160 genomewide association studies. To find out more, visit theHuGE Navigator

The fight against type 2 diabetes: The promise of genomics, Sandra Adamson Fryhofer, Medscape podcast, July 11, 2014

Check out genetic disorders and tests associated with diabetes at the NIH Genetic Testing Registry

Diabetes Complications: Role of Genomics - May 8, 2014

The global diabetes epidemic  "A perfect storm of commerce, lifestyle and genetics", by Kasia Lipska, New York Times, Apr 25

CDC information on diabetes complications: If you have diabetes, it's important to take care of your feet and the rest of your body

The genetics of vascular complications in diabetes mellitus

Dan Farbstein, et al. Cardiol Clin. 2010 Aug;28(3):477-96

Mechanisms of diabetic complications

Forbes JM. Physiol Rev (2013)

Metabolic memory and chronic diabetes complications: Potential role for epigenetic mechanisms

Robert V. Inti et al. Current Diabetes Rep (2013)

Did you know? More than 3300 genes have been reported in relation to risk of type 2 diabetes and its complications? For additional information, visit the HuGE Navigator

Did you know? 19 genomewide association studies have reported on genetic risk in relation to diabetes complications? Find out more from the HuGE Navigator