Hereditary Cancer Genetic Testing: Where are We? - September 1, 2015

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Cancer Genomic Tests

Hereditary Cancer Genetic Testing: Where are We? - September 1, 2015

American Society of Clinical Oncology policy statement update: Genetic and genomic testing for cancer susceptibility
Robson ME et al. J Clinical Oncology, August 2015

Genetic cancer susceptibility testing: increased technology, increased complexity
Yu PP , J Clin Oncology, August 2015

Update on horizon scans of genetic tests currently available for clinical use in cancers
Rockville (MD):Agency for Healthcare Research and Quality (US) 2011 Apr 15.

NCI paper: Prevalence and correlates of receiving and sharing high-penetrance cancer genetic test results: Findings from the Health Information National Trends Survey 
Taber J.M. et al Public Health Genomics, January 2015

Clinical decisions: Screening an asymptomatic person for genetic risk--polling results 
Schulte J, et al. N Engl J Med 2014 Nov;371(20):e30

Testing for hereditary breast cancer: Panel or targeted testing? Experience from a clinical cancer genetics practice.
Doherty J, J Genet Couns. 2014 Dec 5

Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines.
Stoffel EM, et al. J Clin Oncol. 2014 Dec 1

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial.
Manchanda R, et al. J Natl Cancer Inst. 2014 Nov 30;107(1)

Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing. 
Manchanda R et al. J Natl Cancer Inst. 2014 Nov 30;107(1).

Cancer Genomic Tests: Accelerating Translation - October 30, 2014

CDC-NCI paper: An overview of recommendations and translational milestones for genomic tests in cancer 
Christine Q. Chang et al. Genetics in Medicine, October 22, 2014

Check out the CDC evidence-based classification of cancer genomic tests

Check out the NCI Cancer Genomics and Epidemiology Navigator for latest information on cancer genomic tests  

EGAPP: A model process for evaluating genomic applications in practice and prevention. Check out cancer genomic tests, methods, evidence reviews and recommendation statements.

NCI Fact Sheet: Genetic testing for hereditary cancer syndromes