Suicide: Public Health and Genomic Insights - September 9, 2015

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Suicide

Suicide: Public Health and Genomic Insights - September 9, 2015

CDC Info

• Preventing suicide
• Preventing suicide: A comprehensive public health approachCDC Public Health Grand Rounds
• Suicide, family health history, and genomics
• Suicide: risk and protective factors

Preventing suicide

Preventing suicide: A comprehensive public health approach 
CDC Public Health Grand Rounds

Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder.
Kaminsky Z et al. Transl Psychiatry 2015 e627

Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder.
Schaffer A et al. Aust N Z J Psychiatry 2015 Sep (9) 785-802

Genetic polymorphisms might predict suicide attempts in mental disorder patients: A systematic review and meta-analysis.
de Medeiros AV et al. CNS Neurol Disord Drug Targets 2015 (7) 820-7

Suicide: Recent Genomic Insights - March 2, 2015

Genome-wide association studies of suicidal behaviors: a review.
Sokolowski Marcus et al. Eur Neuropsychopharmacol 2014 Oct (10) 1567-77

Two novel genomic rearrangements identified in suicide subjects using a-CGH array.
Lombardo Barbara et al. Clin. Chem. Lab. Med. 2015 Feb 13.

Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.
Breen Marie E et al. Psychiatr. Genet. 2015 Feb 24.

Molecular convergence of neurodevelopmental disorders.
Chen Elizabeth S et al. Am. J. Hum. Genet. 2014 Nov 6. (5) 490-508

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
Mullins Niamh et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014 Jul (5) 428-37

Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression.
Dempster Emma L et al. Biol. Psychiatry 2014 Dec 15. (12) 977-83

A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide.
Di Narzo Antonio Fabio et al. Hum. Mol. Genet. 2014 Sep 15. (18) 4801-13

Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder.
Zai Clement C et al. Neuropsychobiology 2014 (3) 154-8

Epigenetic studies of suicidal behavior.
Bani-Fatemi Ali et al. Neurocase 2015 (2) 134-43

Suicide Prevention: Family Health History & Genomics - September 18, 2014

CDC information: Suicide can be prevented. Each year, more than 39,000 Americans take their own lives and about 487,000 people receive medical care for self-inflicted injuries

New CDC blog post: Suicide, family health history, and genomics

CDC information: Risk factors for suicide include family history of suicide and family health history of child maltreatment

National Institute for Mental Health information: Suicide prevention

Did you know?>200 genes have been reported in relation to suicide risk, including 10 genomewide association studies? To find out more, visit the HuGE Navigator

Check out genetic conditions and tests associated with suicide, from the NIH Genetic Testing Registry

Could a genetic test predict the risk for suicide? Scientists are hunting for the genetic basis of suicide and developing suicide DNA tests, by Antonio Regalado, MIT Technology Review, Aug 13

Blood test that allegedly predicts suicide risk only looks promising in the media, not in science, by Cecile Janssens, Huffington Post, Aug 19

Team approach helps teen depression, by Dr. Francis Collins, NIH Director, Sep 9