MIR145 - microRNA 145 - Genetics Home Reference

MIR145 - microRNA 145 - Genetics Home Reference

MIR145

On this page:

 

• Name 
• Normal function 
• Genetic changes 
• Gene location 
• Additional information
• Other names 
• About genes 
• Glossary definitions

What is the official name of the MIR145 gene?

The official name of this gene is “microRNA 145.”

MIR145 is the gene's official symbol. The MIR145 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MIR145 gene?

The MIR145 gene provides instructions for making microRNA-145 (miR-145). MicroRNAs (miRNAs) are short lengths of RNA, a chemical cousin of DNA. These molecules control gene expression by blocking the process of protein production. MiR-145 is abundant in immature blood cells and controls the expression of hundreds of genes. This microRNA is thought to be involved in normal blood cell development. In particular, miR-145 appears to play a role in the growth and division of blood cells called megakaryocytes, which produce platelets, the cell fragments involved in blood clotting.

How are changes in the MIR145 gene related to health conditions?

5q minus syndrome - associated with the MIR145 gene

The MIR145 gene is involved in a condition called 5q minus (5q-) syndrome. This condition is a type of bone marrow disorder called myelodysplastic syndrome (MDS), in which immature blood cells fail to develop normally. Individuals with 5q- syndrome often have a shortage of red blood cells (anemia) and abnormalities in megakaryocytes. Affected individuals also have an increased risk of developing a fast-growing blood cancer known as acute myeloid leukemia (AML).

5q- syndrome is caused by deletion of a region of DNA from the long (q) arm of chromosome 5. This deletion occurs in immature blood cells during a person's lifetime and affects one copy of chromosome 5 in each cell. Most people with 5q- syndrome are missing a sequence of about 1.5 million DNA building blocks (base pairs), also written as 1.5 megabases (Mb). This deleted region contains 40 genes, including MIR145. Loss of one copy of the MIR145 gene reduces the amount of the microRNA miR-145 in cells. As a result, levels of proteins whose production is normally blocked by miR-145 are elevated, which leads to the abnormal development of megakaryocytes that occurs in 5q- syndrome. Research suggests that the other features of the condition are associated with other genes in the deleted segment of DNA.

Where is the MIR145 gene located?

Cytogenetic Location: 5q32

Molecular Location on chromosome 5: base pairs 149,430,646 to 149,430,733

The MIR145 gene is located on the long (q) arm of chromosome 5 at position 32.

More precisely, the MIR145 gene is located from base pair 149,430,646 to base pair 149,430,733 on chromosome 5.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MIR145?

You and your healthcare professional may find the following resources about MIR145 helpful.

• Educational resources - Information pages
  Stembook (2008): MicroRNA Biogenesis and Function

You may also be interested in these resources, which are designed for genetics professionals and researchers.

• PubMed - Recent literature
• OMIM - Genetic disorder catalog
• Research Resources - Tools for researchers (4 links)

What other names do people use for the MIR145 gene or gene products?

• hsa-mir-145
• miR-145
• MIRN145
• miRNA145

See How are genetic conditions and genes named? in the Handbook.

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

• What is DNA?
• What is a gene?
• How do genes direct the production of proteins?
• How can gene mutations affect health and development?

These links provide additional genetics resources that may be useful.

• Genetics Education
• Human Genome Project
• Resources for Genetics Researchers

What glossary definitions help with understanding MIR145?

acute ; acute myeloid leukemia ; AML ; anemia ; blood clotting ; bone marrow ; cancer ; cell ;chromosome ; clotting ; deletion ; DNA ; gene ; gene expression ; leukemia ; Mb ;myelodysplastic syndrome ; myeloid ; pharmacogenomics ; platelets ; protein ; RNA ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (6 links)

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook