Current Highlight from October 30, 2015
New Mouse Model for Short-Term Photocarcinogenicity Testing
Scientists from NCTR and Washington State University College of Pharmacy have developed a new transgenic hairless albino (THA) mouse model for the detection of gene mutations caused by exposure to ultraviolet radiation (sunlight). Initial experiments have demonstrated that the THA mouse shows significant dose-response increases in skin mutant frequencies in less than a month, supporting its design as a short-term phototoxicity test. The THA mouse, which was developed by crossing the hairless SKH-1 mouse (a standard strain for conducting photocarcinogenicity studies) with the gpt delta mouse (a transgenic mouse that is used for evaluating in vivo gene mutation), carries two transgenic reporter genes that enable the detection of point mutations as well as mutations characterized by large base deletions. The results of this study were recentlypublished in Mutation Research.
For additional information, please contact Mugimane Manjanatha, Ph.D., Division of Genetic and Molecular Toxicology, FDA/NCTR.
Keynote Address at Chinese Society of Toxicology
NCTR Director, William Slikker, Jr., provided the invited keynote address to the Chinese Society of Toxicology in Wuhan, China on Monday, October 26, 2015. Over 1,200 attendees were present to hear his presentation entitled “World Impact of 3D Cell Models and Microphysiological Systems on Drug and Chemical Safety Assessment”. He also visited with the leadership of the National Institute of Food and Drug Control, Chinese FDA and visited their soon-to-open CFDA facility on the outskirts of Beijing.
No hay comentarios:
Publicar un comentario