The microbiome and its pharmacological targets: therapeutic avenues in cardiometabolic diseases.

Neves AL1, Chilloux J1, Sarafian MH1, Rahim MB1, Boulangé CL1, Dumas ME2.

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Abstract

Consisting of trillions of non-pathogenic bacteria living in a symbiotic relationship with their mammalian host, the gut microbiota has emerged in the past decades as one of the key drivers for cardiometabolic diseases (CMD). By degrading dietary substrates, the gut microbiota produces several metabolites that bind human pharmacological targets, impact subsequent signalling networks and in fine modulate host's metabolism. In this review, we revisit the pharmacological relevance of four classes of gut microbial metabolites in CMD: short-chain fatty acids (SCFA), bile acids, methylamines and indoles. Unravelling the signalling mechanisms of the microbial-mammalian metabolic axis adds one more layer of complexity to the physiopathology of CMD and opens new avenues for the development of microbiota-based pharmacological therapies.

KEYWORDS:

3-indoxylsulfate (PubChem CID: 10258); Acetate (PubChem CID: 176); Butyrate (PubChem CID: 264); Chenodeoxycholic acid (PubChem CID: 10133); Cholic acid (PubChem CID: 221493); Deoxycholic acid (PubChem CID: 222528); Indole-3-propionate (PubChem CID: 3744); Propionate (PubChem CID: 1032); Trimethylamine (PubChem CID: 1146); Trimethylamine-N-oxide (PubChem CID: 1145)