C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis.

Psychiatry Res. 2015 Dec 8. pii: S0165-1781(15)30794-0. doi: 10.1016/j.psychres.2015.12.007. [Epub ahead of print]

Last Updated: Jan 08, 2016

• C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis.
  Watson Annie, et al. Psychiatry research 2015 12 (From HuGE Literature Finder)

C9orf72 repeat expansions that cause frontotemporal dementia are detectable among patients with psychosis.

Watson A1, Pribadi M2, Chowdari K1, Clifton S1, Joel Wood1, Miller BL3, Coppola G4, Nimgaonkar V5.

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Abstract

A pathologic hexanucleotide repeat expansion in C9orf72 causes frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). Behavioral abnormalities can also occur among mutation carriers with FTD, but it is uncertain whether such mutations occur among persons with psychoses per se. Among participants in a genetic study of psychoses (N=739), two pairs of related individuals had C9orf72 expansions, of whom three were diagnosed with schizophrenia (SZ) / schizoaffective disorder (SZA), but their clinical features did not suggest dementia or ALS. A few patients with SZ/SZA carry C9orf72 repeat expansions; such individuals are highly likely to develop FTD/ALS.

Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Dementia; Schizoaffective disorder; Schizophrenia

PMID:

 

26723138

 

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