Guidelines for Genomic Array Analysis in Acquired Haematological Neoplastic Disorders.

Schoumans J1, Suela J2, Hastings R3, Muehlematter D1, Rack K4,5, van den Berg E6, Beverloo HB7, Stevens-Kroef M8.

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Abstract

Genetic profiling is important for disease evaluation and prediction of prognosis or responsiveness to therapy in neoplasia. Microarray technologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays have in recent years been introduced into the diagnostic setting for specific types of haematological malignancies and solid tumours. It can be used as a complementary test or depending on the neoplasia investigated, also as a standalone test. However, comprehensive and readable presentation of frequently identified complex genomic profiles remains challenging. To assist diagnostic laboratories, standardization and minimum criteria for clinical interpretation and reporting of acquired genomic abnormalities detected through arrays in neoplastic disorders are presented. This article is protected by copyright. All rights reserved.