domingo, 17 de enero de 2016

High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: a prospective study. - PubMed - NCBI

High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: a prospective study. - PubMed - NCBI
 2016 Jan 8. doi: 10.1111/ijd.12811. [Epub ahead of print]

High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: 

a prospective study.

Abstract

BACKGROUND:

Psoriasis is a chronic inflammatory disease that affects not only the skin but also other 
organs as well. Genetic factors play an important role in individual predisposition. Lately, a positive association 
has been confirmed between psoriasis and metabolic syndrome (MBS), in western as well as in Middle Eastern 
countries.

AIM:

Assess the prevalence of MBS in Lebanese patients with psoriasis and the differential effect according 
to types and disease severity.

METHODS:

This was a case-control study including 150 psoriasis patients and 150 age- and gender-matched 
controls admitted to the dermatology clinics at the American University of Beirut-Medical Center, a tertiary care
center in Beirut. Psoriasis severity was assessed by the Psoriasis Area Severity Index (PASI). Blood samples 
were collected from fasting subjects and tested for glucose, HDL cholesterol, triglycerides, and C-reactive protein 
(CRP). Multivariate binary logistic regression models were built to assess the relationship between MBS and 
psoriasis, after adjustment for smoking as a possible confounding variable.

RESULTS:

Patients with psoriasis were two times more likely to have MBS as compared to controls 
(35.3% vs 18.0%, P < 0.001) with an odds ratio (OR) of 2.4. All components of MBS were more prevalent 
in psoriasis patients than in controls. PASI score was greater in patients with MBS than those without MBS 
(10.5 ± 11.5 vs. 7.0 ± 8.1, P = 0.05). MBS prevalence tended to be higher in the inverse type than in others 
(52.2% versus 32.3%; P = 0.06) and in patients with nail pitting versus those without (45.3% vs. 28.2%; P = 0.03).

CONCLUSIONS:

This was the first study to assess the prevalence of MBS in Lebanese subjects with psoriasis
and, to our knowledge, the first study that showed a higher likelihood of MBS in patients with inverse psoriasis 
and with nail pitting.
© 2016 The International Society of Dermatology.

PMID:
  
26748974
 
[PubMed - as supplied by publisher]



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