Meta-Analysis on the Correlation Between APOM rs805296 Polymorphism and Risk of Coronary Artery Disease.

Sun H1, Shen D1, Zhang C1, Huang D1, Wang Y1, Zhang L1.

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Abstract

BACKGROUND The present meta-analysis aimed to summarize the inconsistent findings on the association of apolipoprotein M gene (ApoM) rs805296 polymorphism with the risk of coronary artery disease (CAD), and to obtain a more authentic result about this topic. MATERIAL AND METHODS A total of 7 available articles were identified through electronic databases - PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) - and their useful data were carefully extracted. The relationship between ApoM rs805296 polymorphism and CAD risk was assessed by odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs), which were calculated using the fixed- or random-effects model, according to the degree of heterogeneity. Hardy-Weinberg equilibrium test, sensitivity test, and publication bias examination were also performed in this meta-analysis. RESULTS According to the pooled results, ApoM rs805296 polymorphism conferred an increased risk of CAD under all the genetic contrasts: CC versus TT, CC + TC versus TT, CC versus TT+TC, C versus T, and TC versus TT (OR=2.13, 95% CI=1.16-3.91; OR=1.80, 95% CI=1.50-2.17; OR=1.91, 95% CI=1.04-3.51; OR=1.72, 95% CI=1.45-2.04; OR=1.78, 95% CI=1.47-2.15). CONCLUSIONS ApoM rs805296 polymorphism may be a risk factor for developing CAD.