REST rs3796529 variant does not influence human subcortical brain structures.

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Abstract

Nho et al. identified the minor allele T of REST missense variant rs3796529 confers a protective effect on right hippocampal loss with corrected p = 0.061 using 315 samples (including n= 135 mild cognitive impairment (MCI) cases) 1 . Meta-analysis of the four remaining cohorts indicate a marginal association of rs3796529 with right hippocampal volume (p = 0.063) 1 . Nho et al. used the Fisher's method to combine 0.061 and 0.063, and got the combined p = 0.025 based on the five independent cohorts (n = 923) 1 . Nho et al. further investigated the association between rs3796529 and hippocampal volume using imaging data of 1566 samples including MCI, Alzheimer's disease (AD) and cognitively normal individuals from Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 . They identified the minor allele T of rs3796529 confers a protective effect on hippocampal loss in both MCI and AD participants, but not the cognitively normal individuals 2 . Nho et al. described that this issue deserves further investigation 2-3 . This article is protected by copyright. All rights reserved.