Schistosomiasis Screening of Travelers to Corsica, France

To the editor: As members of the French Ministry of Health Working Group on autochthonous urinary schistosomiasis, we read with interest the 2 recently published articles regarding schistosomiasis screening of travelers to Corsica, France (1,2). Surprisingly, the authors of both articles lacked evidence to support the diagnosis of schistosomiasis in most of what they referred to as confirmed cases. The diagnostic standard for confirmation of urinary schistosomiasis is identification of eggs by microscopic examination of urine samples (3–5). If this criterion were applied in both reports, only 1 patient of the 7 allegedly confirmed cases would actually be confirmed.

The low sensitivity of microscopy is well known. Therefore, different serologic tests have been developed, including Western blot (WB). In the study based on travelers from Italy (1), the SCHISTO II WB IgG test (LDBIO Diagnostics, Lyon, France) was used. This test, available since 2015, is based on both Schistosoma haematobiumand S. mansoni antigens and has not been evaluated by anyone other than the manufacturer. Moreover, the authors did not report any details regarding the molecular weight and number of specific bands observed on the strip.

In the study by authors from the GeoSentinel Surveillance Network (2), both cases that could have been infected after 2013, since exposure occurred only in 2014, and 4 cases which reported bathing in rivers in Corsica other than the Cavu River had just 1 weakly positive serologic screening test. Hence, irrespective of the criteria for a confirmed case of schistosomiasis described above, it appears difficult to conclude that confirmation could rely on only 1 positive serologic test, even a WB.

Altogether, these 2 studies identified only 1 patient with parasitological evidence of infection that was attributable to the already known 2013 focus in Cavu River. Therefore, these articles do not provide evidence of transmission of schistosomiasis in Corsica after 2013 or outside the Cavu River.

Antoine Berry

, Luc Paris, Jérôme Boissier, and Eric Caumes

Author affiliations: Toulouse University Hospital, Toulouse, France (A. Berry); Public Assistance Hospitals of Paris, Paris, France (L. Paris, E. Caumes);University of Perpignan Via Domitia, Perpignan, France; National Centre of Scientific Research, Perpignan (J. Boissier)

References

Beltrame A, Zammarchi L, Zuglian G, Gobbi F, Angheben A, Marchese V, Schistosomiasis screening of travelers from Italy with possible exposure in Corsica, France. Emerg Infect Dis. 2015;21:1887–9 . DOI PubMed
Gautret P, Mockenhaupt FP, von Sonnenburg F, Rothe C, Libman M, Van De Winkel K, Local and international implications of schistosomiasis acquired in Corsica, France. Emerg Infect Dis. 2015;21:1865–8. DOI PubMed
Gryseels B, Strickland GT. Schistosomiasis. In: Magill AJ, Ryan ET, Hill DR, Solomon T, editors. Hunter’s tropical medicine and emerging infectious diseases, 9th ed. London: Elsevier Saunders; 2013. p. 868.
Maguire JH. Trematodes. Schistosomes and other flukes. In: Mandell GL, Bennett JE, Dolin JE, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases, 7th ed. Philadelphia: Churchill Livingstone Elsevier Philadelphia; 2010. p. 3595–3606.
World Health Organization. WHO recommended surveillance standards. 2nd ed. WHO/CDS/CSR/ISR/99/2/EN. Geneva: The Organization; 2015. p 107 [cited 2015 July 22]. http://www.who.int/csr/resources/publications/surveillance/WHO_CDS_CSR_ISR_99_2_EN/en

Suggested citation for this article: Schistosomiasis screening of travelers to Corsica, France. [letter]. Berry A, Paris L, Boissier J, Caumes E. Emerg Infect Dis. 2016 Jan [date cited]. http://dx.doi.org/10.3201/eid2201.151290

DOI: 10.3201/eid2201.151290