Atherosclerosis. 2015 Dec 11;245:139-142. doi: 10.1016/j.atherosclerosis.2015.12.011. [Epub ahead of print]

• Vitamin D receptor GATG haplotype association with atherosclerotic disease in patients with rheumatoid arthritis.
  López-Mejías Raquel, et al. Atherosclerosis 2015 12 139-142 (From HuGE Literature Finder)

Vitamin D receptor GATG haplotype association with atherosclerotic disease in patients with rheumatoid arthritis.

López-Mejías R1, Genre F1, Remuzgo-Martínez S1, Robledo G2, Llorca J3, Corrales A1, González-Juanatey C4, Ubilla B1, Mijares V1, Pina T1, Blanco R1,Castañeda S5, Martín J2, González-Gay MA6.

Author information

Abstract

INTRODUCTION:

An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDR GAT haplotype is also associated with atherosclerotic disease in RA.

MATERIAL AND METHODS:

591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound.

RESULTS:

VDR rs7975232 AA genotype was increased in RA patients with plaques (p = 0.045, OR = 1.46 [1.01-2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p = 0.009, OR = 1.56 [1.09-2.42]).

CONCLUSION:

Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients.

Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Atherosclerosis; Carotid plaques; Polymorphisms; Rheumatoid arthritis; Vitamin D receptor

PMID:

 

26724524

 

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