04/14/2016 |
3D confocal microscopy datasets of live human mammary epithelial cells (green) using microtentacles (black arrows) to penetrate the junctions (white arrowhead) between blood vessel endothelial cells (red). Cross sections (lower panels) show that microtentacles extend through cell-cell junctions to penetrate underneath the endothelial monolayer (white arrow). A nontumorigenic mammary epithelial cell remains on the endothelial surface (left panels), while a cell that has undergone epithelial-to-mesenchymal transition (right panels) generates microtentacles that penetrate endothelial layers.
NCI Visuals Online: Image Details
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