Current Highlight from April 1, 2016
Size- and Dose-Dependent Antiviral Effects of Silver Nanoparticles
NCTR scientists have demonstrated both size- and dose-dependent antiviral effects of silver nanoparticles (AgNPs) in in vitro assays using feline calicivirus (FCV) as a surrogate for human norovirus. Treatment of cultures with 10 nanometer (nm)-sized AgNPs (at doses of 50 and 100 micrograms per milliliter [µg/mL]) completely inactivated FCV within 2-4 hours of exposure, resulting in a decrease in the viral titer, an absence of cytopathic effects in Crandell-Rees Feline Kidney cells, and a reduction in viral capsid protein levels; whereas no effect was observed with 75 and 110 nm-sized AgNPs. The use of AgNPs as antibacterial agents has increased in consumer-use products; however, its use as an antiviral agent is still an area of active research. This study is now available online at Foodborne Pathogens and Disease
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.For additional information, please contact Sangeeta Khare, Ph.D., Division of Microbiology, FDA/NCTR.
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