Molecular characterization of the first G24P[14] rotavirus strain detected in humans. - PubMed - NCBI
Infect Genet Evol. 2016 May 26. pii: S1567-1348(16)30205-2. doi: 10.1016/j.meegid.2016.05.033. [Epub ahead of print]
Molecular characterization of the first G24P[14] rotavirus strain detected in humans.
Ward ML1,
Mijatovic-Rustempasic S2,
Roy S3,
Rungsrisuriyachai K4,
Boom JA5,
Sahni LC6,
Baker CJ7,
Rench MA8,
Wikswo ME9,
Payne DC10,
Parashar UD11,
Bowen MD12.
Abstract
Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans. Copyright © 2015. Published by Elsevier B.V.
KEYWORDS:
Bovine; G24P[14]; Reassortment; Rotavirus
- PMID:
- 27237948
- [PubMed - as supplied by publisher]
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