Nivolumab
This page contains brief information about nivolumab and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
US Brand Name(s)
Opdivo
Opdivo Injection
Opdivo Injection
FDA Approved
Yes
Use in Cancer
Nivolumab is approved to be used alone or with other drugs to treat:
- Classical Hodgkin lymphoma that has gotten worse after an autologous stem cell transplant and treatment with brentuximab vedotin.
- Melanoma that cannot be removed by surgery or that has metastasized (spread to other parts of the body).
- It is used with ipilimumab in patients whose cancer does not have a certainBRAF gene mutation.
- It is used alone in patients whose disease got worse after being treated with ipilimumab and, if their cancer had a certain BRAF gene mutation, with a drug called a BRAF inhibitor.
- Non-small cell lung cancer that has metastasized. It is used in patients whose disease got worse during or after treatment with platinum chemotherapy. Patients whose cancer has certain gene mutations should receive nivolumab only if their disease got worse after treatment with FDA-approved therapy for the gene mutations.
- Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used in patients who have already received angiogenesis inhibitor therapy.
Nivolumab is also being studied in the treatment of other types of cancer.
More About Nivolumab
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Nivolumab - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Targeted Cancer Therapies - Information about the use of this drug to treat cancer.
Research Results
Clinical Trial Results: Nivolumab-Based Treatments Delay Progression of Advanced Melanoma - Important clinical trial results for this drug, background information, and how the trial was done.
Clinical Trial Results: Nivolumab Improves Overall Survival in Patients With Metastatic Melanoma Without a BRAF Mutation - Important clinical trial results for this drug, background information, and how the trial was done.
With Immunotherapy, Glimmers of Progress Against Glioblastoma - Information from NCI about this drug.
New Therapies Are Changing the Outlook for Advanced Melanoma - Information from NCI about this drug.
Lung Cancer Precision Medicine Trials: Adapting to Progress - Information from NCI about this drug.
Clinical Trials Accepting Patients
Find Clinical Trials for Nivolumab - Check for trials from NCI's list of cancer clinical trials now accepting patients.
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