Mechanisms of vascularization in murine models of primary and metastatic tumor growth | Chinese Journal of Cancer | Full Text

Mechanisms of vascularization in murine models of primary and metastatic tumor growth | Chinese Journal of Cancer | Full Text

Chinese Journal of Cancer

Mechanisms of vascularization in murine models of primary and metastatic tumor growth

• Edina Bugyik†,
• Ferenc Renyi-Vamos†,
• Vanessza Szabo,
• Katalin Dezso,
• Nora Ecker,
• Andras Rokusz,
• Peter Nagy,
• Balazs Dome and
• Sandor PakuEmail author

†Contributed equally

Chinese Journal of Cancer201635:19

DOI: 10.1186/s40880-016-0083-5

©  Bugyik et al. 2016

Received: 7 October 2015

Accepted: 6 January 2016

Published: 12 February 2016

Abstract

Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.

Keywords

Vascularization Primary tumor Metastasis Angiogenesis