Definition of talazoparib - NCI Drug Dictionary - National Cancer Institute

Definition of talazoparib - NCI Drug Dictionary - National Cancer Institute

Terms & Properties

Preferred Name: Talazoparib

Definition: An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

Display Name: Talazoparib

Label: Talazoparib

NCI Thesaurus Code: C95733 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987384  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

BMN-673

BMN 673

Talazoparib

External Source Codes: 

PDQ Closed Trial Search ID	694964
PDQ Open Trial Search ID	694964 (check for NCI PDQ open clinical trial info)
UMLS CUI	C2987384

Other Properties:

Name	Value (qualifiers indented underneath)
code	C95733
Contributing_Source	CTRP
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C95733

talazoparib

An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. Check for active clinical trials using this agent. (NCI Thesaurus)

Code name:

BMN 673 BMN-673