Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines. - PubMed - NCBI
Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines.
Cruz-Correa M1,
Pérez-Mayoral J2,
Dutil J3,
Echenique M4,
Mosquera R5,
Rivera-Román K6,
Umpierre S7,
Rodriguez-Quilichini S7,
Gonzalez-Pons M2,
Olivera MI2,
Pardo S8;
Puerto Rico Clinical Cancer Genetics Consortia.
Abstract
Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network's screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients. KEYWORDS:
Genetic counseling; Genetic testing; Germline mutations; Hereditary cancer; Hispanics
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