viernes, 3 de marzo de 2017

Cancer stem cell metabolism | Breast Cancer Research | Full Text

Cancer stem cell metabolism | Breast Cancer Research | Full Text

Biomed Central



Breast Cancer Research

Cancer stem cell metabolism

  • Maria Peiris-Pagès,
  • Ubaldo E. Martinez-Outschoorn,
  • Richard G. Pestell,
  • Federica SotgiaEmail author and
  • Michael P. LisantiEmail author
Breast Cancer Research201618:55
DOI: 10.1186/s13058-016-0712-6
Received: 12 February 2016
Accepted: 25 April 2016
Published: 24 May 2016



Abstract

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.


Cancer, above all other diseases, has countless secondary causes.
But even for cancer, there is only one prime cause …: metabolism.
Otto Warburg

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