domingo, 28 de mayo de 2017

Dissecting microsatellite instability in colorectal cancer: one size does not fit all | Genome Medicine | Full Text

Dissecting microsatellite instability in colorectal cancer: one size does not fit all | Genome Medicine | Full Text

Biomed Central



Genome Medicine

Dissecting microsatellite instability in colorectal cancer: one size does not fit all

Genome Medicine20179:45
DOI: 10.1186/s13073-017-0438-9
Published: 24 May 2017

Abstract

Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might have consequences for the potential use of immunotherapy in MSI-positive cancers.
See related research by Sveen et al. 10.1186/s13073-017-0434-0

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